Glucosephosphate dehydrogenase (G6PD) deficiency was detected in 16 ( %) of a group of 23 neonates who had unexplained moderate or severe. Of infants, were found to be G6PD deficient. Hiperbilirubinemi; G6PD enzim eksikliği bulunan erkek yenidoğanın 38’inde (%), Screening. This is a blood test to find out whether you have low amounts of an enzyme called glucosephosphate dehydrogenase. Experts estimate that million.

Author: Tygorg Arashigrel
Country: Montenegro
Language: English (Spanish)
Genre: Environment
Published (Last): 23 July 2010
Pages: 165
PDF File Size: 1.28 Mb
ePub File Size: 3.90 Mb
ISBN: 344-5-49415-846-3
Downloads: 42396
Price: Free* [*Free Regsitration Required]
Uploader: Volrajas

Abstract Glucosephosphate dehydrogenase G6PD deficiency is the most common enzyme deficiency worldwide including Malaysia. Mason PJ September When red blood cells lack the G6PD enzyme, they become more prone to harmful elements, and they die sooner than their expected lifespan, a condition referred to as hemolysis. S Wikipedije, slobodne enciklopedije.

A mutation in the G6PD gene causes the enziim blood cells to break down before they should.

Glukozofosfo-dehidrogenaza – Wikipedia

G6pe is widely distributed in many species from bacteria to humans. Uvod u humanu imunogenetiku. Early blood cell destruction is called hemolysis. Two transcript variants encoding different isoforms have been found for this gene.

Since G6PD ejzim an inherited disorder, one of the common concerns of people diagnosed with the condition is the chances of them passing on the disorder to their children.

The proline at position is thought to play a crucial role in positioning Lys correctly with respect to the substrate, G6P. Most of the time, if you have a moderate deficiency of glucosephosphate dehydrogenase, you feel fine. Some people who have the defective gene never have enzkm symptoms. To function properly, the cells need an enzyme called glucose-6 phosphate dehydrogenase G6PD.


As one of the largest medical tourism companies in the region, we are able to secure and share the critical information that is most linked to quality and cost of care. Slightly different view than the first panel.

The red blood cells are responsible for delivering the nutrients and oxygen that the organs need. These cells are produced in the bone marrow and have a lifespan of about days. This page was last edited on 28 Julyat Retrieved 13 December EC number Enzyme superfamily Enzyme family List of enzymes. But triggers can set off hemolysis.

This includes medicines that don’t need a prescription and any illicit drugs you may use.

Interactive Tools

DocDoc has Asia’s largest healthcare physician network with 23, doctors, clinics and 55 hospitals from various specialties throughout the region. Glukozafosfat dehidrogenaza je stimulirana njenim supstratom — glukoza 6 fosfatom. However, this was shown to be incorrect.

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. These include bleeding, infection, bruising, and feeling lightheaded. When a patient is diagnosed with G6PD deficiency, the doctor will analyze what triggered the condition. If you have only a mild to moderate deficiency and you have an important reason to take a medicine that will trigger hemolysis, your healthcare provider may offer you a low dose of the trigger medicine and monitor your blood count closely.


Be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking. Studies have shown that people with G6PD deficiency display a natural immunity to malaria. In higher plants, several isoforms of G6PDH have been reported, which are localized in the cytosolthe plastidic stromaand peroxisomes. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway.

The prevalence of partial G6PD deficiency in female neonate group was 3. Red blood cell enzymopathies. A newborn with G6PD deficiency can be born with jaundice. The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage from compounds like hydrogen peroxide.

Log In or Register Home My profile.

Once a person is diagnosed with the disorder, the next step is to identify the correct variant. The Biochemical Journal, Pt 2: Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator. Phosphopentose isomerase Phosphopentose epimerase Transketolase Transaldolase.